Stroke-Biomarkers.com

Etiology

Etiology

Stroke is one of the main causes of death and disability in the world. However, there are still several medical limitations in stroke prevention, diagnosis and treatment. One promising field under investigation is the use of biomarkers to guide stroke etiologic diagnosis and classification, since treatment differs among etiologic subtypes (cardioembolic, atherosclerotic and lacunar stroke) and many patients currently receive a diagnosis of undetermined stroke. In the future, the use of these biomarkers will allow clinicians to rapidly guide other diagnostic tests and accelerate the onset of an optimal secondary prevention.

Etiologies

Symbol Description Associations Endpoint Genecards
1N86 D-dimer D-dimer is a fibrin degradation product. It is increased in acute phase of ischemic stroke and is associated with a high risk of recurrence and with cardioembolic etiology. It has been also associated with poor outcome and mortality. Similar levels have been determined in both subtypes of stroke during acute phase. Atherothrombotic, Cardioembolic Link
CID 5460048 Triglycerides High levels of triglycerides have been associated with large artery atherosclerotic stroke Atherothrombotic, Lacunar Link
P01584 IL1B Cytokines may contribute to both neurotoxicity and neuroprotection. IL1beta has been found elevated in ischemic stroke patients compared to mimics. No clear association has been found with aetiological classification of ischemic stroke Cardioembolic Link
P02671 FIBA Higher levels of circulating fibrinogen are associated with long-term poor outcome and death after stroke and with increased risk of ischemic stroke, but not provides incremental value over traditional risk factors. The association between fibrinogen levels and aetiological subtypes of ischemic strokes is not concordant in different studies. Cardioembolic Link
P02741 CRP Independent of other cardiovascular risk factors, elevated plasma CRP levels significantly predict the risk of future ischemic stroke and TIA in the elderly. In ischemic stroke patients, high CRP circulating levels within 24h from onset are associated with poor long-term functional outcome [2]. No clear association has been found with aetiological classification of ischemic stroke. No diferences at plasma levels between hemorragic and ischemic stroke. Cardioembolic, Lacunar, Atherothrombotic Link
P02768 ALBU Baseline Ischemia-Modified Albumin (IMA) blood levels may be a biomarker for early identification of acute stroke, but not to differentiate Ischemic from hemorrhagic stroke patients. On the other hand, serum albumin is decreased in those patients who die following a stroke. No significant association has been found between vWf levels and aetiological subtypes of ischemic stroke. No ignificant difference at plasma level between stroke subtypes. Cardioembolic, Lacunar, Atherothrombotic Link
P04271 S100B Higher levels of S100B in ischemic stroke patients than healthy controls, showing a trend to be higher in those patients with poor outcome at third month after stroke. Also, high S100B leves have been associated with hemorrhagic transformation and brain edema. No clear association has been found between S100B levels and aetiological classification of ischemic stroke. Higher plasma levels were found in intracerebral hemorrhage than ischemic stroke patients. Atherothrombotic, Cardioembolic Link
P04275 VWF Higher circulating levels in stroke patients with functional disability at third month after the event. No significant association has been found between vWf levels and aetiological classification of ischemic stroke Atherothrombotic, No, Cardioembolic Link
P05231 IL6 IL6 has been studied in stroke patients regarding stroke incidence, recurrence and prognosis and higher levels of IL6 have been associated with all of these endpoints. It has also been proposed as a predictor of infections. No significant association has been found between IL6 levels and aetiological subtypes of ischemic stroke Cardioembolic, No Link
P16581 LYAM2 E-selectin does not show significant differences in ischemic stroke patients comparet to patients with TIA when measured in plasma during the first 12 h after onset but is associated with increased risk of ischemic stroke. No significant association has been found between E-selectine levels and aetiological subtypes of ischemic stroke Atherothrombotic Link
P16860 ANFB High circulating levels of BNP/NT-proBNP are associated with poor outcome after stroke, although only minor predictive value is added to clinical information [2]. High BNP levels indicate an embolic origin for stroke patients. Similar levels have been determined in both subtypes of stroke. Cardioembolic Link
SID 17848324 Cholesterol Total Cholesterol levels has been associated with cardiovascular risk and with large artery atherosclerotic stroke. No association with stroke outcome has been observed. Atherothrombotic, Lacunar Link
SID 53789957 LDL_Cholesterol Its prognostic value in stroke has been assessed with negative results [1]. It has been described as surrogate marker for hemorrhagic transformation [2]. It is associated with large artery atherosclerotic (LAA) stroke Atherothrombotic, Lacunar Link

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.