Stroke-Biomarkers.com

Q9HD89

  • Synonyms:Resistin, Adipose tissue-specific secretory factor, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein Cysteine-rich secreted protein A12-alpha-like 2
  • Biomarker name:RETN
  • Gene name:RETN
  • Gene id:56729
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=RETN
  • Biomarker function:Is a cysteine-rich adipocytokine that seems to suppress insulin ability to stimulate glucose uptake into adipose cells [1] Potentially links obesity to diabetes. Also current evidence appears to suggest that has chaperone-like properties.[2].The oligomeric form shows more potent effect on stimulation of proinflammatory cytokines.[3][4]
  • Neurovascular unit:No
  • Intracellular location:Secreted
  • Body fluids:Plasma, Serum
  • Prot-prot interactions:Yes:
  • Inductors:Unknown
  • Inhibitors:Unknown
  • Signaling pathway:Yes:
  • Biological process:Inflammatory response, Lipid metabolism
  • Comments:--
  • Associations:Changes in resistin plasma levels were observed in the course of stroke and might be associated with worse neurological deficits. Also is significantly associated with increased risk of ischemic stroke and improves net reclassification in the traditional risk factor model.
  • References:[1] McTernan PG et al, Resistin.Curr Opin Lipidol. 2006 Apr;17(2):170-5. [2]Suragani M et al, Human resistin, a proinflammatory cytokine, shows chaperone-like activity. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51) [3]Oltean S et al, Increased resistin in brain dead organ donors is associated with delayed graft function after kidney transplantation.J Transl Med. 2013 Sep 26;11:233 [4]Aruna B et al. Biophysical analyses of human resistin: oligomer formation suggests novel biological function. Biochemistry. 2008 Nov 25;47(47)

Source articles by endpoint

Risk
Endpoint Articles
StrokePrugger C, 2012; Prugger C, 2013;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.