Stroke-Biomarkers.com

Q15109

  • Synonyms:Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products
  • Biomarker name:RAGE
  • Gene name:AGER
  • Gene id:177
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=AGER&search=sRAGE
  • Biomarker function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.RAGE
  • Neurovascular unit:Vessel
  • Intracellular location:Membrane, Secreted
  • Body fluids:Plasma, Serum
  • Prot-prot interactions:Unknown
  • Inductors:Unknown
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:Inflammatory response
  • Comments:-
  • Associations:RAGE has been associated with ischemic stroke, and it may be a plasma biomarker to differenciate ischemic from hemorrhagic stroke. Ischemic stroke patients present raised plasma levels than hemorrhagic stroke patients.
  • References:-

Source articles by endpoint

Subtype
Endpoint Articles
Ischemic strokeMontaner J, 2012;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.