- Synonyms:LDL-associated phospholipase A2
- Biomarker name:PAFA
- Gene name:PLA2G7
- Gene id:GC06M046719
- Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=PLA2G7&search=PLA2G7
- Biomarker function:Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques.
- Neurovascular unit:No
- Intracellular location:Secreted
- Body fluids:Plasma, Serum
- Prot-prot interactions:Yes: TBA1A, ESR1, GRID2, CHPT1, IGF1
- Signaling pathway:Yes: cAMP-Dependent PKA; PAK ,PTEN, PKC-Theta
- Biological process:Lipid metabolism
- Comments:The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and seems to be closely correlated to cardiovascular events.
- Associations:Lipoprotein associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker which provides information on plaque inflammation and stability. Data from epidemiological studies have shown that is a risk factor for primary and secondary ischemic stroke.
- References:Miklishanskaia SV et al. Clinical role of lipoprotein-associated phospholipase A2.Kardiologiia. 2013;53(3):59-70; Fontes JD et al. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study..Atherosclerosis. 2013 May;228(1):217-23; Delgado P. et al.Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients. J.Cerebrovasc Dis. 2012;33(2).
Source articles by endpoint
|No||Delgado.P, 2012; Satoh.K, 1992; Delgado.P, 2012;|
|Stroke||Wassertheil-Smoller S, 2008;|