Stroke-Biomarkers.com

Q13093

  • Synonyms:LDL-associated phospholipase A2
  • Biomarker name:PAFA
  • Gene name:PLA2G7
  • Gene id:GC06M046719
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=PLA2G7&search=PLA2G7
  • Biomarker function:Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques.
  • Neurovascular unit:No
  • Intracellular location:Secreted
  • Body fluids:Plasma, Serum
  • Prot-prot interactions:Yes: TBA1A, ESR1, GRID2, CHPT1, IGF1
  • Inductors:Unknown
  • Inhibitors:Yes:
  • Signaling pathway:Yes: cAMP-Dependent PKA; PAK ,PTEN, PKC-Theta
  • Biological process:Lipid metabolism
  • Comments:The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and seems to be closely correlated to cardiovascular events.
  • Associations:Lipoprotein associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker which provides information on plaque inflammation and stability. Data from epidemiological studies have shown that is a risk factor for primary and secondary ischemic stroke.
  • References:Miklishanskaia SV et al. Clinical role of lipoprotein-associated phospholipase A2.Kardiologiia. 2013;53(3):59-70; Fontes JD et al. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study..Atherosclerosis. 2013 May;228(1):217-23; Delgado P. et al.Lipoprotein-associated phospholipase A(2) activity is associated with large-artery atherosclerotic etiology and recurrent stroke in TIA patients. J.Cerebrovasc Dis. 2012;33(2).

Source articles by endpoint

Risk
Endpoint Articles
NoDelgado.P, 2012; Satoh.K, 1992; Delgado.P, 2012;
StrokeWassertheil-Smoller S, 2008;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.