Stroke-Biomarkers.com

P26022

  • Synonyms:Pentraxin-related protein PTX3, TNF alpha-induced protein 5, TSG-14
  • Biomarker name:PTX3
  • Gene name:PTX3
  • Gene id:5806
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTX3
  • Biomarker function:Acute phase protein. Regulation of innate immune system and inflammation. Member of the pentraxin superfamily, together with CRP.
  • Neurovascular unit:Vessel
  • Intracellular location:Secreted
  • Body fluids:Plasma
  • Prot-prot interactions:Unknown
  • Inductors:Yes: IL-1b, TNFa
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:Acute phase, Inflammatory response
  • Comments:PTX3 levels might reflect the underlying burden of atherosclerosis [1].
  • Associations:Higher plasma PTX3 levels are associated with mortality after stroke.
  • References:1. Rolph MS et al. Production of the long pentraxin PTX3 in advanced atherosclerotic plaques. Arterioscler Thromb Vasc Biol 2002;22:e10-4.

Source articles by endpoint

Prognosis
Endpoint Articles
ExitusRyu WS, 2012;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.