Stroke-Biomarkers.com

P14780

  • Synonyms:Matrix metalloproteinase-9, Gelatinase B
  • Biomarker name:MMP9
  • Gene name:MMP9
  • Gene id:4318
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=MMP9&search=MMP9
  • Biomarker function:Role in local proteolysis of the extracellular matrix and in leukocyte migration. Cleaves type IV and type V collagen. Degrades fibronectin but not laminin.
  • Neurovascular unit:Extracellular matrix
  • Intracellular location:Secreted
  • Body fluids:Plasma, Serum, CSF
  • Prot-prot interactions:Yes:
  • Inductors:Unknown
  • Inhibitors:Yes:
  • Signaling pathway:Unknown
  • Biological process:Collagen degradation
  • Comments:Its proteolytic action over the extracellular matrix is related with angiogenesis processes.
  • Associations:Associated with BBB disruption. Positively correlated with stroke severity and infart volume within acute phase of ischemic stroke. Raised plasma MMP-9 in stroke patients than mimics. Its relationship with poor outcome is not clear. Similar levels have been determined in both subtypes of stroke during acute phase.
  • References:-

Source articles by endpoint

Diagnosis
Endpoint Articles
StrokeGlickman SW, 2011; Montaner J, 2011;
Prognosis
Endpoint Articles
DisabilityRodríguez-Yáñez M, 2013;
HTMontaner J. , 2001; Castellanos M. , 2003; Montaner J., 2003; Castellanos M. , 2004; Castellanos M. , 2007;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.