Stroke-Biomarkers.com

P09429

  • Synonyms:High mobility group protein B1, amphoterin
  • Biomarker name:HMGB1
  • Gene name:HMGB1
  • Gene id:3146
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMGB1
  • Biomarker function:DNA binding protein, mainly ssDNA. Member of the family of alarmins, molecules that signal tissue and cell damage. HMGB1 augments inflammation by binding RAGE and TLR receptors.
  • Neurovascular unit:Neuron
  • Intracellular location:Nucleus, Secreted
  • Body fluids:Plasma, Serum, CSF
  • Prot-prot interactions:Unknown
  • Inductors:Unknown
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:
  • Comments:-
  • Associations:Higher circulating levels of HMGB1 are associated with poor outcome 1 year after stroke.
  • References:-

Source articles by endpoint

Prognosis
Endpoint Articles
DisabilityHuang JM, 2013;
ExitusHuang JM, 2013;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.