Stroke-Biomarkers.com

P04275

  • Synonyms:von Willebrand factor
  • Biomarker name:VWF
  • Gene name:VWF
  • Gene id:7450
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=VWF
  • Biomarker function:Blood glycoprotein involved in the maintenance of hemostasis by adhering platelets to the sites of vascular injury. Chaperone for coagulation factor VIII.
  • Neurovascular unit:Vessel, Extracellular matrix
  • Intracellular location:Secreted
  • Body fluids:Plasma, Serum, Urine, CSF
  • Prot-prot interactions:Yes:
  • Inductors:Unknown
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:Cell adhesion, Hemostasis
  • Comments:Defects on VWF protein result in impaired platelet aggregation, leading to hemorrhages (von Willebrand disease).
  • Associations:Higher circulating levels in stroke patients with functional disability at third month after the event. No significant association has been found between vWf levels and aetiological classification of ischemic stroke
  • References:-

Source articles by endpoint

Etiologies
Endpoint Articles
AtherothromboticCherian P, 2003;
CardioembolicTuttolomondo A, 2009;
NoTuttolomondo A, 2009;
Prognosis
Endpoint Articles
DisabilityWhiteley W, 2012;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.