Biomarker function:Binds calcium and zinc. Mediates in calcium-dependent modulation of physiological processes. Also, S100B is involved in regulation of protein phosphorylation in brain tissue.
Intracellular location:Cytoplasm, Nucleus
Body fluids:Plasma, Serum, CSF
Biological process:Cell cycle
Comments:S100B is associated with astrocyte damage and with increased BBB permeability.
Associations:Higher levels of S100B in ischemic stroke patients than healthy controls, showing a trend to be higher in those patients with poor outcome at third month after stroke. Also, high S100B leves have been associated with hemorrhagic transformation and brain edema. No clear association has been found between S100B levels and aetiological classification of ischemic stroke.
Higher plasma levels were found in intracerebral hemorrhage than ischemic stroke patients.