Stroke-Biomarkers.com

P02792

  • Synonyms:Ferritin
  • Biomarker name:FRIL
  • Gene name:FTL
  • Gene id:2512
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=FTL
  • Biomarker function:Role in iron homeostasis, storing iron and delivering it to cells. In that way, Ferritin avoids iron toxicity and the formation of free radicals.
  • Neurovascular unit:Microglia, Other:
  • Intracellular location:Cytoplasm
  • Body fluids:Plasma, Serum
  • Prot-prot interactions:Yes:
  • Inductors:Yes:
  • Inhibitors:Yes:
  • Signaling pathway:Unknown
  • Biological process:Acute phase, Iron storage
  • Comments:Ferritin stands as an spherical oligomer, having light and heavy chains. Genetic mutations in FTL gene cause a neurodegenerative disorder associated with iron accumulation [1]. Ferritin concentration increase in the presence of infection [2] and hypoxia [3].
  • Associations:In stroke, high ferritin levels have been associated with hemorrhagic transformation and outcome.
  • References:1. Maciel P et al. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem. 2010, 285:11948-57. 2. Krol V et al. Diagnostic significance of serum ferritin levels in infectious and non-infectious diseases. Infect Dis Pract. 2003, 27:199-200. 3. Qi Y et al. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem. 1995, 64(6):2458-64.

Source articles by endpoint

Prognosis
Endpoint Articles
ExitusÜstündağ M, 2010;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.