Biomarker function:Fibrinogen polymerizes to form fibrin in the coagulation cascade after thrombin activation. Moreover, it is a cofactor in platelet aggregation.
Body fluids:Plasma, Serum, Urine, CSF
Biological process:Acute phase, Hemostasis
Comments:Fibrinogen is an heterohexamer formed by α, β, and γ chains. It is synthesized in the liver. Fibrinogen is an inflammatory marker.
Associations:Higher levels of circulating fibrinogen are associated with long-term poor outcome and death after stroke and with increased risk of ischemic stroke, but not provides incremental value over traditional risk factors. The association between fibrinogen levels and aetiological subtypes of ischemic strokes is not concordant in different studies.