Stroke-Biomarkers.com

P02671

  • Synonyms:Fibrinogen
  • Biomarker name:FIBA
  • Gene name:FGA
  • Gene id:2243
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=FGA
  • Biomarker function:Fibrinogen polymerizes to form fibrin in the coagulation cascade after thrombin activation. Moreover, it is a cofactor in platelet aggregation.
  • Neurovascular unit:No
  • Intracellular location:Secreted
  • Body fluids:Plasma, Serum, Urine, CSF
  • Prot-prot interactions:Yes:
  • Inductors:Yes:
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:Acute phase, Hemostasis
  • Comments:Fibrinogen is an heterohexamer formed by α, β, and γ chains. It is synthesized in the liver. Fibrinogen is an inflammatory marker.
  • Associations:Higher levels of circulating fibrinogen are associated with long-term poor outcome and death after stroke and with increased risk of ischemic stroke, but not provides incremental value over traditional risk factors. The association between fibrinogen levels and aetiological subtypes of ischemic strokes is not concordant in different studies.
  • References:-

Source articles by endpoint

Etiologies
Endpoint Articles
CardioembolicTamura H, 2012;
Prognosis
Endpoint Articles
DisabilityWhiteley W, 2012;
ExitusShibazaki K, 2011;
Risk
Endpoint Articles
StrokePrugger C, 2013;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.