Stroke-Biomarkers.com

P01185

  • Synonyms:Vasopressin-neurophysin 2-copeptin
  • Biomarker name:NEU2
  • Gene name:AVP
  • Gene id:551
  • Genecards link:http://www.genecards.org/cgi-bin/carddisp.pl?gene=AVP&search=avp
  • Biomarker function:Copeptin is a cleaved fragment of AVP-NPII which functions as a hypothalamic hormone. Neurophysin 2 specifically binds vasopressin. Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
  • Neurovascular unit:Unknown
  • Intracellular location:Secreted
  • Body fluids:Plasma
  • Prot-prot interactions:Unknown
  • Inductors:Unknown
  • Inhibitors:Unknown
  • Signaling pathway:Unknown
  • Biological process:cAMP biosynthesis
  • Comments:Copeptin is secreted in equimolar ratio to AVP, but is more stable in circulation [1].
  • Associations:Copeptin adds predictive information on functional outcome and mortality at long-term.
  • References:1. Morgenthaler NG et al. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem, 2006; 52: 112-119.

Source articles by endpoint

Diagnosis
Endpoint Articles
StrokeZhang JL, 2013;
Prognosis
Endpoint Articles
DisabilityKatan M., 2009; Zweifel C, 2010; Urwyler SA., 2010; Zhang X., 2012; Dong X., 2013; De Marchis GM, 2013; Zhang JL, 2013; Tu WJ, 2013; Tu WJ., 2011; Yu WH. , 2014;
ExitusKatan M., 2009; Zweifel C, 2010; Urwyler SA., 2010; Zhang X., 2012; Dong X., 2013; De Marchis GM, 2013; Zhang JL, 2013; Tu WJ, 2013; Yu WH. , 2014;
InfectionFluri, F, 2012;
WorseningZhang X., 2012;

Neurovascular Research Laboratory - Vall d'Hebron Research Institute (VHIR). 2013. Last update: 2017-03-28 12:25:27h.